The below tables contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics such as half-life and equivalent doses to other benzodiazepines also listed, along with their trade names and primary uses. The elimination half-life is how.
Other benzodiazepines are also listed for comparison purposes, but it does not however include binding data for;. A large number of benzodiazepine derivatives have been synthesised and their structure-activity relationships explored in detail. This chart contains binding data for benzodiazepines and related drugs investigated by Roche up to the late 1990s (though in some cases the compounds were originally synthesised by other companies such as Takeda or Upjohn ).
For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual.
III. Preparations: Benzodiazepines Equivalents. Alprazolam (Xanax). Alprazolam 0.5 mg is equivalent to 10 mg Diazepam · Valium = Dose x20; Phenobarbital = Dose x30. Chlordiazepoxide (Librium, Limbitrol). Chlordiazepoxide 25 mg is equivalent to 10 mg Diazepam · Valium = Dose x0.4; Phenobarbital = Dose x1.2.
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This page was written by Scott Moses, MD, last revised on 4/24/2013 and last published on 12/6/2017.
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There is insufficient evidence to strongly support the use of one particular benzodiazepine for tapering. Convert to equivalent dose in divided doses. (See Table B Appendix 6.1 Benzodiazepine Equivalent Table.) Adjust initial dose according to symptoms (equivalence table is approximate). Decreasing the Dose. Taper by.
— Source: Adapted from Kahan 2002.
— Source: Adapted from Kalvik 1995, Canadian Pharmacists Association 1999.
* Equivalences are approximate. **Equivalency uncertain. Careful monitoring is required to avoid oversedation, particularly in older adults and those with impaired hepatic metabolism.
(Benzodiazepine) (Dose Comparison) (Peak) (Half-life) Alprazolam 0.25 1-2hrs. 9-20hrs. (Xanax) Bromazepam 3.0 0.5-4hrs. 8-30hrs. (lexotan) Chlordiazepoxide 12.5 1-4hrs. 24-100hrs. (librium) Clobazepam 10 .5-4hrs. 12-60hrs.
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